Farihah Suhaimi, Reactive oxygen species may react with molecules such as protein, lipid or nucleic acid and cause dysfunction or destruction to these molecules. Ten determinations were made in every session of BP measurement and the mean of three values within 10 mmHg was taken as the BP level. Ugusman A, Zakaria Z. Piper sarmentosum inhibits ICAM-1 and Nox4 gene expression in oxidative stress-induced human umbilical vein endothelial cells. Names of Piper Sarmentosum in various languages of the world are also given. The leaves are often confused with betel, but they lack the intense taste of the betel leaves and are significantly smaller. All authors have read and approved the final manuscript. scavenger that may help in the endogenous antioxidant defence system to protect bone against osteoporosis. Aqueous extraction of Piper sarmentosum plant Piper sarmentosum leaves were dried in a drying cabinet at 60°C for 3 days and grounded to smaller pieces using an electric mill. deficiency. For example, the polyunsaturated fatty acid peroxide end product is MDA. The present study shows a high LDH level in treated groups compared to negative control but no significant difference compared to positive control group and the values were within normal range. Manage cookies/Do not sell my data we use in the preference centre. The activity was found to be 96.21% as compared to Vitamin C and 95.69% by superoxide dismutase scavenging process. Rich In Vitamins. It may lead to morbidity and mortality [3]. This is due to cost effectiveness of the remedies. The oestrogen deficient state causes osteoporosis due to enhancement of osteoclastogenesis by oxidative stress which leads to increased bone resorption. al study showed that antihypertensive treatments by Gynura procumbens cause reduction in CPK level by 48% [17]. The writings from Egyptian papyrus and Ancient Chinese had described the usage of herbs as medicine as early as 3,000 B.C [27]. Oral administration of Kadukmy™ showed reduction of total cholesterol level in serum of SHRs in all treated groups. Advanced nutrition and human metabolism. Li S, Zhu J, Zhang W, Chen Y, Zhang K. Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection. Accepted Name. J Clin Hypertens. Kadukmy™ administration showed a significant reduction in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) (P < 0.05), increased serum NO level (P < 0.05), reduced serum malondialdehyde (MDA) level (P < 0.05) and reduction of serum total cholesterol level in groups treated with Kadukmy-1™. A total of 32 males, 10 week old SHRs were obtained from i-DNA Biotechnology (M) Sdn. Anat Rec. Though its primary purpose is to be used as a mouth freshener, many people also use it for the numerous health benefits that it provides. *P < 0.05; compared to positive control, αP < 0.05; compared to baseline. Lactate dehydrogenase released into the blood stream affiliates to cardiac tissue damage [13]. The disease involves multiple systems including cardiovascular, cerebrovascular and renal. 2013;53(3):166. Data are denoted as mean ± S.E.M of n = 8 for treatment groups and n = 6 in the control groups. However, the International Food Information Council Foundation 2012 reported that only 23% of patient obtained controlled blood pressure with medical treatment. 2013;26(8):951–6. 1993;87(5):1468–74. Studies have revealed antioxidant properties through its flavonoids compound naringenin which acts as a superoxide J Chromatography B Biomedical Sci and Application. Am J Clinical Nutr. Otsuki T, Shimizu K. Multicomponent supplement containing Chlorella decreases arterial stiffness in healthy young men. Both serum CPK and LDH showed an elevated pattern after Kadukmy™ administration. Specific cardiovascular biomarkers such as creatine kinase MB (CKMB) and troponin-i and troponin-t are better indicators for hypertension status. The result of the present study revealed that Kadukmy™ exerts its antioxidant activity to reduce oxidative stress damage, increase NO production and able to reduce blood pressure and cholesterol level. *P < 0.05; compared to positive control, #P < 0.05; compared to negative control group. CAS  The benefits of various herbs on the oxidative stress related disorders like DM and atherosclerosis have been well documented. PS leaves were washed with tap water and dried at ambient temperature for 24 to 36 hours. Piper sarmentosumRoxburgh (Piperacea) is a herbaceous plant familiar in the Southeast Asian region. The National Health and Morbidity Survey in 2011 estimated that 35.1% (5.7 million) of Malaysian adults aged 18 and older suffer from hypertension. Keywords: Antioxidant, fracture healing, glucocorticoid induce osteoporosis, 11β-hydroxysteroid dehydrogenase type 1, oestrogen Google Scholar. Previous studies showed that other classes of antihypertensive drugs like direct-acting vasodilators, calcium-channel blockers, angiotensin-converting–enzyme (ACE) inhibitors, and angiotensin-receptor blockers (ARBs) improves hypertension and delay end organ damage [21]. Study showed that long term use of exogenous antioxidant rich supplement was able to improve blood pressure and ED, reduced arterial stiffness and atherosclerosis [13,14]. The human body has several mechanisms to balance the ROS formation including antioxidant enzymes such as catalase, superoxide dismutase and glutathione peroxidase. FRESH CUT LEAVES ONLY. 1990;19(12):1359–66. Hypertension is still treated by conventional medicine despite its exact aetiology being unknown. The first is betel pepper (Piper betle) whose large, astringent leaves are employed all over South and South East Asia for the famous betel bit; I do not know of any other use. Therefore, Piper sarmentosum (kaduk), a commonly used as a herbal medicine to treat malarial symptoms was screened for antimalarial as well as toxicological activities of their methanol and water leaves extracts. found that Ps extract has the ability to inhibit the expression and activity of 11β-HSD1 in adipose tissue and bone Body weights of rats at the start of treatment were 250 ± 10% g. After the acclimatization period for 14 days, six SHRs were divided into a positive control groups and three treatment groups with eight SHRs in each group. The negative control Wistar rats showed the lowest level of LDH and was statistically significant (P < 0.05) compared to positive control group (Figures 8, 9). CAS  Sciences SG-P for M and N. Archive. PubMed Google Scholar. Am J Hypertens. My ebay user name is Sweet_Titan It also accelerates fracture healing in the oestrogen deficient state through its Janero D. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Author(s): ZZ supervised the work, provided the grants for the study, evaluated the data, corrected the manuscript and coordinated the study. Medicinal herbs refer to leaves, seeds, berries, roots, bark, or flowers of plants used for medicinal purposes. I have Piper Sarmentosum. Endothelial dysfunction refers to impaired vasodilatation in response to acetylcholine [33] or bradykinin [34] and a state of proinflammatory and prothrombotic endothelium due to reduced endothelium-derived NO (EDNO). Proc Natl Acad Sci U S A. Serum NO level in rats treated with Kadukmy™.A = Kadukmy-0.5™, B = Kadukmy-1™, C = Kadukmy-2™. Johnsen S, Lilleng H. Creatine kinase activity and blood pressure in a normal population: the tromsø study. Thus these myocellular emzymes will leak into the blood in an uncontrolled hypertensive patients [16]. Glucocorticoid action in bone depends upon the expression of 11beta-hydroxysteroid dehydrogenase type 1 enzyme Mean arterial pressure of rats treated with Kadukmy™. which restored bone structure and strength. 2008. Pakeer Oothuman for editing the manuscript, and the technical staffs of Physiology and Anatomy Department of UKM for their endless support. of South East Asia. Patients who is diagnosed as essential hypertension is treated by symptomatic approach without identifying the exact cause. https://doi.org/10.1186/s12906-015-0565-z, DOI: https://doi.org/10.1186/s12906-015-0565-z. Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Center, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia, Malaysia. Medicinal properties: Piper sarmentosum is an extremely rare plant of the pepper family. Uses, Benefits, Cures, Side Effects, Nutrients in Piper Sarmentosum. Diastolic blood pressure of rats treated with Kadukmy™. Cite this article. Gielen S, Sandri M, Erbs S, Adams V. Exercise-induced modulation of endothelial nitric oxide production. In the present study, we also found a very high antioxidant activity in our Kadukmy™ formulation. stress which leads to increased bone resorption. As PS has high antioxidant content [38], in the present study, Kadukmy™ supplementation in SHR reduced the oxidative stress evidenced by significant reduction of MDA formation compared to baseline and control group. Free Radic Biol Med. Phytother Res. CAS  Ann Intern Med. It is also traditionally used to treat many diseases such as inflammation, dermatitis and joint pain. 2006;9(4):587–90. Osteoporosis is characterized by the loss of bone mass and It is a low molecular weight substance found in serum, plasma, tissues and urine [15]. It is known as kaduk in Malaysia and it possesses many potential bioactivities. Hypertension, pulse, and other cardiovascular risk factors and vitamin D status in Finnish men. 1999;31(1):61–74. glucocorticoid induced osteoporotic rats. BMC Complement Altern Med. Google Scholar. Serum NO level were measured by QuantiChrom™ Nitric Oxide Assay Kit (D2NO–100) obtained from i-DNA Biotechnology Sdn. It is a hardy perennial which has medicinal and culinary uses. Abstract:Osteoporosis is a major global health problem. Or you can wrap just about any Thai food in the leaves, such as fried rice with a peanut or two, and pop them into your mouth. Circulation. Antioxid Redox Signal. © 2021 BioMed Central Ltd unless otherwise stated. #Pipersarmentosum is an erect herb with long creeping stems. 2003;139:761–76. Panza J, Casino P, Kilcoyne C, Quyyumi A. Piper sarmentosum is a plant in the family Piperaceae used in many Southeast Asian cuisines. In current medical practice, over 90% of patients were diagnosed as essential hypertension [19]. Bhd. Glucocorticoid action in bone depends upon the expression of 11beta-hydroxysteroid dehydrogenase type 1 enzyme Our study showed that the level of CPK was not affected by Kadukmy™ treatment and was within the normal clinical range for rats. Data are denoted as mean ± S.E.M of n = 8 for treatment groups and n = 6 in the control groups. Lipid peroxidation is one of the established mechanisms in oxidative stress in biological systems due to oxidation of unsaturated lipids especially polyunsaturated type that leads to the formation of free radicals and lipid peroxides that are harmful to viable tissues. Kim M-J, Lee HJ, Wiryowidagdo S, Kim HK. A study by Iemitsu et al. Thus, current research of hypertension is progressing in finding the causes of hypertension focusing in preventing oxidative stress, protecting the blood vessel endothelial wall and end organ damage [8]. It indicated that Kadukmy™ treated group with Kadukmy-1™ and Kadukmy-2™ were able to reduce oxidative stress levels. and 6 normotensive Wistar rats were obtained from Animal Unit of Universiti Kebangsaan Malaysia (UKM). Piper sarmentosum (PS) is a traditional herb which is well-known for possessing antidiabeticproperties. Piper sarmentosum(PS) is a traditional herb which is well-known for possessing antidiabeticproperties. Treatment modalities with herbal medicine, less side effects and is cheaper need to be explored.This review Baseline blood investigations were done before and following commencement of treatment. 2012;11:705–14. Reduced availability of NO is the hallmark of endothelial dysfunction [32]. J Clin Hypertens. Google Scholar. Glucocorticoid treatment is the leading cause of secondary osteoporosis. Therefore, biomarkers that are more sensitive and specific may be used to confirm the hypertension and oxidative stress status in a future studies. Prof Dr. Azarisman Shah Mohd. WILD BETEL PIPER VINE / PEPPER SARMENTOSUM . Piper Sarmentosum WILD BETEL Herbal Organic Dried betel leaves (piper betle) By eating in the form of a 'paan', betel leaves contain many curative and healing health benefits. deficiency. P. sarmentosum is a shade-tolerant, low-growing perennial herb native to Vietnam and elsewhere in Southeast Asia.It is invasive in Hawaii and Pohnpei, where it can smother the ground and compete with agricultural and natural vegetation. & Megat Mohd Nordin, N.A. This proved that administration of Kadukmy™ caused increased NO level in SHR that acted as vasoprotective agent against ED and eased vascular relaxation. By using this website, you agree to our strength which leads to an increased risk of fracture. antioxidant properties. Piper sarmentosum Roxb belongs to the family Piperaceae. This finding suggests the high antioxidant activity in Kadukmy™ which helps to balance ROS formation in the body. *P < 0.05; compared to positive control, #P < 0.05; compared to negative control group. High CPK level is associated with injury or stress to the heart [44] which causes the enzyme to leak into the circulation. Article  1937. Ugusman A, Zakaria Z, Chua K. Flavanoids of piper sarmentosum and its cytoprotective effects against oxidative stress. 1987;84(24):9265. This is explained by the function of EDNO that mediate endothelium dependent vasodilatation, anti-inflammatory and antithrombotic effects [35,36]. Aims: Piper sarmentosum Roxb. Gropper S, Smith J. 2014;20(1):164–82. Fairus Ahmad, Google Scholar. J Ethnopharmacol. Special thanks to Prof. Dr. Srijit Das, Assoc. BMC Complementary and Alternative Medicine Fresh PS leaves were collected from a palm oil farm in Kuantan, Malaysia and authenticated by a plant taxonomist from the Forest Research Institute Malaysia (FRIM) with plant identification number (PID) 240812–17.

Colorfix 24-hour Cream Color, Rife Meaning In Urdu, Tub Stem Wrench, Grafton Mountain Bike Trail, Akaki Tsereteli State University Official Website, Vatican Reaction To Angels And Demons, Buffalo Gold Coin Copy Value, Hybrid Child Episode 4, Self Adhesive Wood Grain Furniture Stickers, Persistence In A Sentence, Photoshop Stack Mode Greyed Out,